AlmiRNA(s)DovepressmiR1273p, miR-148b, miR376a, miR376c, miR

AlmiRNA(s)DovepressmiR1273p, miR-148b, miR376a, miR376c, miR4093p, miR652, miRsubmit your manuscript | www.dovepress.commiR133a, miR-148bmiRmiR-148b, miR376c, miR4093p, miRmiR-155, miRmiRmiRNotes: That is a representative sample of 20 recent research identified on a PubMed query (breast cancer blood miRNA miR) that describe individual miRNAs or miRNA signatures possessing possible application for early disease detection. Research with fewer than 20 BC cases have been excluded. Though these signatures primarily reflect larger amounts of circulating miRNAs, some miRNAs are detected at lower levels in blood samples of BC patients. Blood collection was performed prior to surgery PeretinoinMedChemExpress Peretinoin unless otherwise indicated. miRNAs shown in bold indicate a recurrent presence in a minimum of 3 independent studies. Abbreviations: BC, breast cancer; DCiS, ductal carcinoma in situ; eR, estrogen receptor; LN, lymph node status; miRNA, microRNA; qRTPCR, quantitative realtime polymerase chain reaction.Breast Cancer: Targets and Therapy 2015:DovepressDovepressmicroRNAs in breast cancerTable two miRNArelated danger loci related to BCGene locus MIR27A SNP rs895919 *C Comments Population Asians Caucasians Jewish BRCA2 carriers Caucasian Asians Caucasians Chinese (young) Chinese Asians Caucasians African Americans African Americans european Americans Chinese Chinese African Americans european Americans African Americans european Americans italian Caucasians Chinese Asians Caucasians Asians Asians Caucasians Chinese Asians Caucasians Chinese Asians Caucasians African Americans African Americans Korean italian and German Asians Caucasians Brazilian Caucasian Chinese and Korean Chinese Chinese African Americans european Americans Asians Caucasians African Americans european Americans African a0023781 Americans African Americans european Americans African Americans european Americans Asians Caucasians Clinical observation No threat BMS-791325MedChemExpress Beclabuvir association Protective dar.12324 increased risk Decreased threat No danger association Decreased danger Decreased risk Decreased risk No danger association No danger association increased survival No danger association Decreased all round threat improved risk elevated danger No danger association improved all round risk Decreased risk of eR+ BC No threat association earlier age of onset No risk association No risk association No danger association No danger association Decreased danger (C allele) No danger association No threat association No risk association No threat association No danger association No risk association No danger association No threat association Reduced danger Decreased danger Survival of HeR2+ instances No danger association Decreased risk No risk association Decreased danger Decreased threat Decreased threat elevated threat elevated threat No risk association No threat association No risk association No danger association Decreased danger of eR- BC No threat association elevated survival enhanced danger of eR- BC No threat association No threat association enhanced all round risk No danger association No threat association Reference 141 142 143 144 35 34 31 145 33 38 38 33 33 146 147 83 38 144 31 36 38 36 31 145 145 148 37 141 149 147 32 36 83 33 31 33 145 33 33rs895819 A/GpremiRNA premiRNA premiRNA premiRNAMIR34B cluster MIR100 MIR101-2 MIR106B MIR122A MIR146Ars4938723 T/C rs1834306 G/A rs1053872 C/G rs462480 A/C rs1527423 A/G rs17669 A/G rs2910164 G/C Principal transcript Key transcriptMIRrs2292832 T/GMIR185 MIR196A-rs2008591 C/T rs887205 A/G rs11614913 T/CMIR204 MIR206 MIR219 MIR331 MIRrs7861254 G rs6920648 A/G rs107822 G/A rs.AlmiRNA(s)DovepressmiR1273p, miR-148b, miR376a, miR376c, miR4093p, miR652, miRsubmit your manuscript | www.dovepress.commiR133a, miR-148bmiRmiR-148b, miR376c, miR4093p, miRmiR-155, miRmiRmiRNotes: That is a representative sample of 20 recent studies located on a PubMed query (breast cancer blood miRNA miR) that describe individual miRNAs or miRNA signatures obtaining potential application for early illness detection. Research with fewer than 20 BC circumstances had been excluded. Although these signatures mostly reflect larger amounts of circulating miRNAs, some miRNAs are detected at lower levels in blood samples of BC sufferers. Blood collection was performed before surgery unless otherwise indicated. miRNAs shown in bold indicate a recurrent presence in at least three independent studies. Abbreviations: BC, breast cancer; DCiS, ductal carcinoma in situ; eR, estrogen receptor; LN, lymph node status; miRNA, microRNA; qRTPCR, quantitative realtime polymerase chain reaction.Breast Cancer: Targets and Therapy 2015:DovepressDovepressmicroRNAs in breast cancerTable two miRNArelated danger loci associated with BCGene locus MIR27A SNP rs895919 *C Comments Population Asians Caucasians Jewish BRCA2 carriers Caucasian Asians Caucasians Chinese (young) Chinese Asians Caucasians African Americans African Americans european Americans Chinese Chinese African Americans european Americans African Americans european Americans italian Caucasians Chinese Asians Caucasians Asians Asians Caucasians Chinese Asians Caucasians Chinese Asians Caucasians African Americans African Americans Korean italian and German Asians Caucasians Brazilian Caucasian Chinese and Korean Chinese Chinese African Americans european Americans Asians Caucasians African Americans european Americans African a0023781 Americans African Americans european Americans African Americans european Americans Asians Caucasians Clinical observation No risk association Protective dar.12324 elevated threat Decreased danger No threat association Decreased risk Decreased threat Decreased threat No danger association No danger association elevated survival No threat association Decreased all round threat enhanced threat improved danger No danger association increased all round danger Decreased threat of eR+ BC No threat association earlier age of onset No threat association No threat association No risk association No threat association Decreased danger (C allele) No risk association No threat association No threat association No risk association No threat association No threat association No risk association No risk association Lowered threat Decreased danger Survival of HeR2+ situations No danger association Decreased danger No threat association Decreased danger Decreased threat Decreased danger improved risk enhanced threat No threat association No risk association No risk association No danger association Decreased threat of eR- BC No danger association elevated survival elevated danger of eR- BC No threat association No threat association elevated general danger No threat association No threat association Reference 141 142 143 144 35 34 31 145 33 38 38 33 33 146 147 83 38 144 31 36 38 36 31 145 145 148 37 141 149 147 32 36 83 33 31 33 145 33 33rs895819 A/GpremiRNA premiRNA premiRNA premiRNAMIR34B cluster MIR100 MIR101-2 MIR106B MIR122A MIR146Ars4938723 T/C rs1834306 G/A rs1053872 C/G rs462480 A/C rs1527423 A/G rs17669 A/G rs2910164 G/C Main transcript Major transcriptMIRrs2292832 T/GMIR185 MIR196A-rs2008591 C/T rs887205 A/G rs11614913 T/CMIR204 MIR206 MIR219 MIR331 MIRrs7861254 G rs6920648 A/G rs107822 G/A rs.