Product Name :
ABTL-0812
Description:
ABTL-0812 (α-Hydroxylinoleic acid) induces endoplasmic reticulum (ER) stress-mediated autophagy. ABTL-0812 is a first-in-class small molecule with anti-cancer activity.
CAS:
57818-44-7
Molecular Weight:
296.44
Formula:
C18H32O3
Chemical Name:
(9Z,12Z)-2-hydroxyoctadeca-9,12-dienoic acid
Smiles :
CCCCC/C=C\C/C=C\CCCCCCC(O)C(O)=O
InChiKey:
AFDSETGKYZMEEA-HZJYTTRNSA-N
InChi :
InChI=1S/C18H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(19)18(20)21/h6-7,9-10,17,19H,2-5,8,11-16H2,1H3,(H,20,21)/b7-6-,10-9-
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ABTL-0812 (α-Hydroxylinoleic acid) induces endoplasmic reticulum (ER) stress-mediated autophagy. ABTL-0812 is a first-in-class small molecule with anti-cancer activity.|Product information|CAS Number: 57818-44-7|Molecular Weight: 296.44|Formula: C18H32O3|Chemical Name: (9Z,12Z)-2-hydroxyoctadeca-9,12-dienoic acid|Smiles: CCCCC/C=C\C/C=C\CCCCCCC(O)C(O)=O|InChiKey: AFDSETGKYZMEEA-HZJYTTRNSA-N|InChi: InChI=1S/C18H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(19)18(20)21/h6-7,9-10,17,19H,2-5,8,11-16H2,1H3,(H,20,21)/b7-6-,10-9-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 5 mg/mL (16.87 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Pinacidil} medchemexpress|{Pinacidil} Potassium Channel|{Pinacidil} Protocol|{Pinacidil} In Vivo|{Pinacidil} manufacturer|{Pinacidil} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Oxiracetam} site|{Oxiracetam} Agonist|{Oxiracetam} Epigenetics|{Oxiracetam} Technical Information|{Oxiracetam} Formula|{Oxiracetam} manufacturer} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33297802 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ABTL-0812 (ABTL0812; 10-100 μM; 48 hours) inhibits cell viability of squamous NSCLC H157 cells. Compared with squamous NSCLC H157 cells, human lung fibroblast cell line MRC-5 are resistant to ABTL0812 treatment.|In Vivo:|ABTL-0812 (ABTL0812; 120 mg/kg; oral gavage; 5 times per week; for 33 d) induces ER stress in human lung and pancreatic xenografts. ABTL-0812 induces hallmarks of ER stress in vivo. ABTL-0812 increases ATF4 and HSPA5 expression in mice bearing MiaPaca2 and A549 xenograft, respectively.|Products are for research use only. Not for human use.|
