S limitations No serious limitations Severe limitations (-1)d Undetected None LowAbbreviations: GRADE, Grading of

S limitations No serious limitations Severe limitations (-1)d Undetected None LowAbbreviations: GRADE, Grading of Recommendations Assessment, Improvement, and Evaluation; RCT, randomized controlled trial. a See Threat of Bias Table A5. b Insufficient information have been offered by Han et al60 to assess effect size and self-confidence intervals. c Perez et al62 had wide self-assurance intervals surrounding effect estimate, which includes both advantage and harm with intervention. Only summary of impact and statistical significance was offered by Han et al.60 d Self-assurance intervals are wide, spanning extremely massive benefit to no effect.Table A13: GRADE Proof Profile for the Comparison of NeuroIDgenetix-Guided Remedy Selection With Remedy as Usual–ResponseNo. of Research (Design) Risk of Bias Inconsistency Indirectness Imprecision Publication Bias Upgrade Considerations QualityResponse Primarily based on 17-Item RIP kinase drug Hamilton Depression Rating Scale 1 (RCT) Pretty significant limitations (-2)a No significant limitations No Really serious limitations No serious limitations Undetected None LowAbbreviations: GRADE, Grading of Recommendations Assessment, Improvement, and Evaluation; RCT, randomized controlled trial. a See Risk of Bias Table A5.Ontario Overall health Technology Assessment Series; Vol. 21: No. 13, pp. 114, AugustAugustTable A14: GRADE Proof Profile for Comparison of Genecept-Guided PIM3 drug Treatment Choice With Remedy as Usual–ResponseNo. of Research (Design) Threat of Bias Inconsistency Indirectness Imprecision Publication Bias Upgrade Considerations QualityResponse Based on 17-Item Hamilton Depression Rating Scale 1 (RCT) Really serious limitations (-1)a No serious limitations No severe limitations Severe limitations (-1)b Undetected None LowResponse Based on Clinical Worldwide Impression Scale–Improvement 1 (RCT) Serious limitations (-1)a No serious limitations No severe limitations Severe limitations (-1)c Undetected None LowAbbreviations: GRADE, Grading of Suggestions Assessment, Improvement, and Evaluation; RCT, randomized controlled trial. a See Risk of Bias Table A5. b Self-confidence intervals span each increased danger and modest benefit. c Confidence intervals span each improvement and tiny to no distinction.Table A15: GRADE Evidence Profile for Comparison of Unspecified Pharmacogenomic-Guided Remedy Choice and Remedy as Usual–ResponseNo. of Studies (Design and style) Threat of Bias Inconsistency Indirectness Imprecision Publication Bias Upgrade Considerations QualityResponse Based on 17-Item Hamilton Depression Rating Scale 1 (RCT) Really serious limitations (-1)a No really serious limitations No really serious limitations Severe limitations (-1)b Undetected None LowAbbreviations: GRADE, Grading of Suggestions Assessment, Development, and Evaluation; HAM-D17, 17-item Hamilton Depression Rating Scale; RCT, randomized controlled trial. a See Danger of Bias Table A5. b Study had very compact sample size and was unlikely to meet optimal info size. Confidence intervals span each large benefit and potential harm.Ontario Health Technologies Assessment Series; Vol. 21: No. 13, pp. 114, AugustAugustTable A16: GRADE Proof Profile for Comparison of GeneSight-Guided Treatment Selection With Remedy as Usual–RemissionNo. of Studies (Style) Risk of Bias Inconsistency Indirectness Imprecision Publication Bias Upgrade Considerations QualityRemission Primarily based on HAM-D17 2 (RCT) 1 (observational) Extremely serious limitations (-2)a Really serious limitations (-1)a No really serious limitations No severe limitations No serious l.