Product Name :
SLF
Description:
SLF is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF can be used in the synthesis of PROTAC.
CAS:
195513-96-3
Molecular Weight:
524.65
Formula:
C30H40N2O6
Chemical Name:
(1R)-1-(3-aminophenyl)-3-(3, 4-dimethoxyphenyl)propyl (2S)-1-(3, 3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
Smiles :
CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCC1C=C(OC)C(=CC=1)OC)C1=CC(N)=CC=C1
InChiKey:
IIDSDBBDZNDWCN-BJKOFHAPSA-N
InChi :
InChI=1S/C30H40N2O6/c1-6-30(2,3)27(33)28(34)32-17-8-7-12-23(32)29(35)38-24(21-10-9-11-22(31)19-21)15-13-20-14-16-25(36-4)26(18-20)37-5/h9-11,14,16,18-19,23-24H,6-8,12-13,15,17,31H2,1-5H3/t23-,24+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
SLF is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF can be used in the synthesis of PROTAC.|Product information|CAS Number: 195513-96-3|Molecular Weight: 524.65|Formula: C30H40N2O6|Chemical Name: (1R)-1-(3-aminophenyl)-3-(3, 4-dimethoxyphenyl)propyl (2S)-1-(3, 3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate|Smiles: CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCC1C=C(OC)C(=CC=1)OC)C1=CC(N)=CC=C1|InChiKey: IIDSDBBDZNDWCN-BJKOFHAPSA-N|InChi: InChI=1S/C30H40N2O6/c1-6-30(2,3)27(33)28(34)32-17-8-7-12-23(32)29(35)38-24(21-10-9-11-22(31)19-21)15-13-20-14-16-25(36-4)26(18-20)37-5/h9-11,14,16,18-19,23-24H,6-8,12-13,15,17,31H2,1-5H3/t23-,24+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (238.{{Dihydroergotamine} web|{Dihydroergotamine} 5-HT Receptor|{Dihydroergotamine} Protocol|{Dihydroergotamine} Description|{Dihydroergotamine} supplier|{Dihydroergotamine} Autophagy} 25 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{DPH} site|{DPH} Bcr-Abl|{DPH} Technical Information|{DPH} Data Sheet|{DPH} manufacturer|{DPH} Autophagy} |Shelf Life: ≥360 days if stored properly.PMID:32119453 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Three scout fragments-KB02, KB03, and KB05 are fused, which cover two different electrophile groups (chloroacetamide and acrylamide) and display broad cysteine reactivity in the human proteome-to the SLF ligand that binds tightly and selectively to FKBP12, a cytosolic prolyl isomerase that has been frequently used to study ligand-induced protein degradation.|References:|Kolos JM, et al. FKBP Ligands-Where We Are and Where to Go? Front Pharmacol. 2018 Dec 5;9:1425.Wu X, et al. Creating diverse target-binding surfaces on FKBP12: synthesis and evaluation of a rapamycin analogue library. ACS Comb Sci. 2011 Sep 12;13(5):486-95.Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746.Products are for research use only. Not for human use.|
